Dr. Tan Hui Li

Doctoral research

on

Fabrication and characterisation of injectable composite hydrogel as a potential scaffold for tissue engineering

Abstract

Tissue and organ failure due to injuries and other damages is one of the most costly medical problem. In order to deal with the issues of expensive therapies and severe donor organs shortage, scientists have made advancement to a new approach in biomedical sciences called tissue engineering. The fundamental principle of tissue engineering is that cells, genes or proteins are 

delivered through degradable material, termed an artificial extracellular matrix (ECM) or scaffold for tissue regeneration. Among various types of biomaterials, hydrogel is a class of biomaterial with high scaffolding potential for tissue engineering applications. A self-healing injectable hydrogel is advantageous because it is able to regenerate the integrated network and stays at the area of injection. This project is carried out to fabricate an injectable and self-healing hydrogel using carboxymethylcellulose and carboxymethylchitosan. The hydrogel will be reinforced using graphene oxide nanofibers, in order to enhance the properties of hydrogel such as mechanical strength. A series of characterisation tests, in vitro and in vivo studies will be carried out to evaluate the potential of the hydrogel as a biomaterial for tissue engineering and drug delivery.

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